Observations on survival curve analysis with particular reference to breast cancer treatment

Observations on folate absorption with particular reference to folate polyglutamate and possible inhibitors to its absorption.

A test system for detection of inhibitors to the enzyme which removes the glutamic acid peptide chain from folate polyglutamates (folate conjugase) is described. This utilizes the reaction between plasma conjugase and the folate polyglutamate in red blood cell haemolysate. Diphenylhydantoin and yeast extracts did not inhibit plasma conjugase. The better absorption of monoglutamate forms of fola...

Breast cancer incidence and nutritional status with particular reference to body weight and height.

The epidemiological literature on breast cancer is reviewed with particular emphasis on the possible etiological role of nutritional status as reflected by weight and height. The results of a prospective study and preliminary results of a population-based case-control study seem to indicate that body size or body mass rather than overweight (obesity) is a risk factor. A considerable proportion ...

Sciatica, with particular reference to its causes and treatment.

Treatment and survival on advanced breast cancer.

The final results of a clinical trial comparing endocrine with cytotoxic drug treatment for advanced breast cancer were analysed. Although cytotoxic treatment gave a significantly higher response rate with a remission duration comparable to that obtained with endocrine treatment, the sequence in which the two treatments were given did not appear to influence survival--except possibly in women w...

Some Observations on the Diet of Jamaican Children, with Particular Reference to Liver Disease

Clinical material studied. During the past I 5 months, I 15 cases of liver disease have been investigated in this Department by Hill (1951) and Hill & Rhodes (1951). Ninety liver biopsies were performed on fifty-eight of the cases by the needle technique and, in addition, ten post-mortem specimens were examined. Though the majority of these patients looked chubby and well nourished, all had an ...